منابع مشابه
Overview of glucose signaling in mesangial cells in diabetic nephropathy.
Clinical studies such as the Diabetes Control and Complications Trial (DCCT) in subjects with type 1 diabetes (1), the UK Prospective Diabetes Study (UKPDS) in subjects with type 2 diabetes (2), and the Kumamoto Study in Japanese subjects with type 2 diabetes (3) clearly link longstanding hyperglycemia to diabetic nephropathy. Furthermore, the regression of glomerular pathologic changes by the ...
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Diabetic nephropathy is a leading cause of chronic kidney disease and end stage renal disease and accounts for significant morbidity and mortality in diabetic patients. Hyperglycemia may lead to end stage renal damage through both metabolic and non metabolic pathways. The non-enzymatic glycation of proteins with irreversible formation and deposition of reactive advanced glycation end products (...
متن کاملAn overview of diabetic nephropathy: Epidemiology, pathophysiology and treatment
Article points 1. Diabetic nephropathy is a complication of both type 1 and type 2 diabetes and is associated with other diabetes-related complications. 2. Diabetic nephropathy is characterised by an increased urinary albumin excretion in the absence of other renal diseases. The earliest clinical evidence of nephropathy is the presence of low but abnormal levels of albumin in the urine, which i...
متن کاملDiabetic Nephropathy AGE, RAGE, and Diabetic Nephropathy
Diabetes is a disease that is present worldwide and which is associated with a large number of potential complications including chronic kidney disease (CKD). Several factors have been implicated in the development of the latter, including advanced glycation end-products (AGEs), which are formed from the interaction between sugar and proteins. AGE toxicity may be triggered via different mechani...
متن کاملRosmarinic Acid Ameliorates Diabetic Nephropathy in Uninephrectomized Diabetic Rats
Objective(s) Oxidative stress plays an important role in diabetic nephropathy pathogenesis. Rosmarinic acid, a plant phenolic compound, was first used as an antioxidant agent for inhibition of diabetic nephropathy. Material and Methods Forty male rats were uninephrectomized from the left flank.The rats were divided in four groups randomly; group one as control, group two diabetic untreatment...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2003
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000065608.37756.58